ABSTRACT
We report a rare case of massive orbital myiasis following recent lid injury, occurring in the empty socket of an elderly lady, who had concurrent scalp pediculosis. The orbital myiasis was effectively treated with the broad-spectrum antiparasitic agent, ivermectin, thus precluding the need for an exploratory surgery. Ivermectin was also effective in managing the concurrent scalp pediculosis.
Subject(s)
Animals , Antiparasitic Agents/therapeutic use , Eye Infections, Parasitic/drug therapy , Female , Follow-Up Studies , Humans , Ivermectin/therapeutic use , Lice Infestations/complications , Myiasis/drug therapy , Orbit/parasitology , Orbital Diseases/drug therapy , Pediculus , Scalp Dermatoses/complications , Scalp Dermatoses/parasitologyABSTRACT
Two simple and sensitive spectrophotometric methods have been developed for the estimation of fenofibrate in pure and pharmaceutical dosage forms. Method A and B are based on ion association complex formation of the drug with Methylene Blue and Saffranine respectively. Beers law is obeyed in the concentration range of 5-15 μg/ml (Method A) and 10-30μg/ml (Method B) with good correlation coefficients. These methods have been statistically evaluated and found to be precise and accurate.
ABSTRACT
A simple and sensitive isocratic RP‐HPLC method was developed for the determination of Nitroxazepine hydrochloride in bulk drug and its pharmaceutical tablet formulations where the mobile phase optimized was Phosphate buffer : Acetonitrile (70:30) and Phenomenex C18 column (250 mm length, 4.6 mm internal diameter and particle size 5 μm) was used as the stationary phase. The flow rate and detection wavelength was 1.0 mL min‐1 and 265 nm respectively. The developed method was validated as per ICH guidelines for specificity, linearity and range, precision, accuracy, robustness, limit of quantification and limit of detection. The results of all the validation parameters were well within their acceptance values. The method gave good recovery in the range of 98.95‐99.43 % for Nitroxazepine hydrochloride when it was applied for its determination in pharmaceutical tablet formulations.
ABSTRACT
We report a rare case of orbital swelling presenting one year after head trauma. An initial fine needle aspiration cytology revealed it to be an infected organizing hematoma. However, broad-spectrum antibiotics did not resolve the infection and the orbital lesion continued to grow in size, as evaluated by magnetic resonance imaging. Incisional biopsies were done, which were reported as orbital actinomycosis. Patient has responded well to treatment with penicillin. This case is of interest due to the delayed presentation of an orbital complication of head trauma and the rare infection with actinomyces. It also highlights the importance of using appropriate antibiotics, as well as the need for long-term treatment.